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Research

Intracardiac Electrophysiology Solutions

Overview

Intracradiac Action Potentials

Intracardiac electrical potentials look similar to a surface ECG. Multiple signals from different locations can be recorded simultaneously and analyzed from a single catheter.

Overview

iWorx offers minimally invasive 8-electrode catheters for studying intracardiac electrical potentials in the rodent. Intracardiac electrophysiology catheters allow for in depth analysis of biopotential propagation through the heart. Up to 4 regional intracardiac electrograms can be recorded simultaneously. The same catheter can be used to pace the heart while recording electrical activity.

Applications:

  • His Bundle characterization
  • SA node characterization
  • General signal propagation
  • Endocardial ECG assessment
  • Regional atrial assessment
  • Conduction studies
  • Qualification of cardiac insult

 

Systems

Systems

iWorx offers turnkey Intracardiac Electrical Potential Recording and Measurement Systems which include data recorders, amplifiers, cables, catheters and software. Each system has been configured to address the subject being studied and acquisition requirements.

*Note: systems and components can be customized for your unique application. Please contact an iWorx Applications Specialist for details*

Mouse System

This turnkey system is configured specifically for recording up to 4 intracardiac electrical potentials from an octapolar electrophysiology catheter for rodents. This configuration also includes the ability to simultaneously pace the heart using any 2 catheter electrodes. The system includes the iWorx IX-RA-834 Recorder, 1.2F Cardiac Electrogram Catheters for mice and interface box, cables and the iWorx LabScribe2 ECG Analysis Module.

Rat System

This turnkey system is configured specifically for recording up to 4 intracardiac electrical potentials from an octapolar electrophysiology catheter for rodents. This configuration also includes the ability to simultaneously pace the heart using any 2 catheter electrodes. The system includes the iWorx IX-RA-834 RAecorder, 1.9F Cardiac Electrogram Catheters for rats and interface box, cables and the iWorx LabScribe2 ECG Analysis Module.

Components

Components

iWorx Intracardiac Electrical Potential Recording and Measurement Systems include data recorders, amplifiers, cables, catheters and software. Each system has been configured to address the subject being studied and acquisition requirements. Click on the links below for more information on each component.

Catheters and Interface Box
Cath-SCI CathetersCATH-SCI-MO-120 1.2F Cardiac Electrogram CatheterCATH-SCI-RO-190 1.9F Cardiac Electrogram Catheter
Catheter Interface BoxA-CEG-CIB Catheter Interface Box (includes extension Cable)
Electrodes and Cables
C-ISO-GNE3C-ISO-GNE and GNE5 Platinum Subdermal Needle Electrode
C-ISO-2mmM CableC-ISO-2mmM Safety Pin Connector (2mm Pins to BNC)
C-BNC-2mmM CableC-BNC-2mmM Stimulator Cable РBNC to 2mm Male Pin (EP interface box)
C-HVS-2mmM CableC-HVS-2mmM Stimulator Cable – Set of 2 Safety Connector to 2mm Male Pin
FC-EPEC-4 Cable with Interface BoxFC-EPEC-4
Recorders
IX-RA-834 Recorder
IX-RA-834 8-Channel RecorderiWorx RA Recorder is the foundation for iWorx advanced research systems. Whether your work involves assessing cardiac performance, analyzing oxygen consumption and carbon dioxide production for exercise physiology, or measuring some other physiological parameter, iWorx RA provides the ease of use and flexibility to speed your research.
iWire Devices
TA 4 Channel Biopotential

iWire-BIO4

iWire-BIO4 4-Channel Biopotential iWire Recording Module
 C-ISO-B3G_250iWire-B3G Isolated ECG/EMG/EEG/GSR iWire Recording Module

Software

LabScribe ECG Analysis Module

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Software

iWorx LabScribe2 ECG Software Module is a powerful and user-friendly tool intended to automate the analysis of ECG data from a variety of species. Specific analysis templates are included to accurately delineate PQRST onset, durations and amplitudes. Custom templates can also be created based on unique ECG profiles and saved to a library for future use.

Other features include beat averaging, beat classification and outlier removal based on abnormal R-R intervals, heart rate, noise and activity, Pointcaré plots and scattergrams and the ability easily extract source data and average data as images or text files. The LabScribe2 ECG Software Module includes a comprehensive list of 24 calculations including R-R, PR, QT, QR and QTc intervals, QRS, T, P and TP durations, P, Q, R, S, T amplitudes and ST elevation.

The software module is plug and play compatible with all iWorx data acquisition and analysis systems. A separate ASCII Text Import Module is also available that enables import of ECG data in text format that was recorded by any other acquisition program.

ECG Calculations:Heart Rate Variability (HRV*) Calculations:
– Heart Rate
– Time at R
– R-R Interval
– Delta R-R
– PR Interval
– P Duration
– QSR Duration
– QT Interval
– QTc Interval
– QR Interval
– ST Segment
– T Duration
– TP Duration
– QATN
– P Amplitude
– R Amplitude
– T Amplitude
– QR Amplitude
– ST Height
– T Area
– Max dR/dt
– Delta R-R
– Low Power
– High Power
– Mean Power at Low Band
– Mean Power at High Band
*Note: HRV can be derived from either an ECG trace or a blood pressure trace.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

LS-30CM Cardiac Module

LS-30TXT ASCII Import Module The iWorx ASCII Import Module enables import of data in text format that was recorded in any other data acquisition program. The module also allows the researcher to use the analysis functions in LabScribe software on data they may previously recorded with another a different program.

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