Making Physiology Happen



Normalization is a separately licensed module designed specifically to calibrate small vessel size for the use of wire myographs in vessel contractility experiments.

In order to make comparisons between different vessels and experimental conditions, an internal circumference that exerts a Target Pressure needs to be determined to make comparisons meaningful.

The relaxed vessel wall is stretched to a number of micrometer settings for a specific size myograph.

The vessel wall force in response to each stretch is recorded by using the Add Point command.

After a curve is generated from these forces, the Calculate command is used to determine the internal circumference at a Target Pressure, usually 13.3kPa.

The normalized internal circumference is usually determined to be
90% of this value.

Details about using the Normalization module are in the LabScribe Manual