Research
Pigs
ECG/EMG
To measure ECG and EMG the recommended systems are:
Technotes:Analysing ECG’s recorded in LabScribe with Kubios HRVPerform MVC calculations in LabScribe.EMG analysis using LabScribeSoftware:ECG : LS-30ECG : LabScribe ECG Software Module is a powerful and user-friendly tool intended to automate the analysis of ECG data from a variety of species.
To measure ECG and EMG the recommended systems are: | MultiLeadThis system includes the IX-BIO4 or the IX-BIO8 or the IX-ECG12 biopotential recorder. This configuration is a cost effective solution for those only interested in measuring ECG/EMG. The gain, high-pass filter setting and low-pass filter setting can be configured via software. |
 | Multi Lead ExpandableSeveral options are available depending on the research protocol and the need to acquire other signals (pressure, volume, flow, etc.) in addition to ECG. Our multi-channel systems have software configurable gains, high-pass and low-pass filter settings. These systems allow for simultaneous recording of up to 12 ECG leads (lead I, lead II, lead III, aVR, aVL and aVF and the 6 chest leads). |
Blood PressureProper assessment of cardiac function and hemodynamic performance requires a measurement of pressure from within the heart and peripheral arteries. iWorx offers several solutions for measuring pressure including fluid‐filled pressure transducers, catheter-tipped micro pressure sensors and non‐invasive tail cuff pressure systems.LabScribe software with the Blood Pressure Module provides built‐in software routines to perform a number of arterial and ventricular pressure calculations
Software LS-BP The LabScribe Blood Pressure Module acquires and analyzes data from blood pressure transducers. Data can be analyzed from ventricular and arterial signals in real-time. The software automatically calculates common indices of function from the blood pressure signal where it can easily be exported to another program for further analysis.Arterial Pressure Calculations:LS-30BP The LabScribe Blood Pressure Module acquires and analyzes data from blood pressure transducers. Data can be analyzed from ventricular and arterial signals in real-time.The software automatically calculates common indices of function from the blood pressure signal where it can easily be exported to another program for further analysis.
Detailed information about using the modules is in the LabScribe Manual
Proper assessment of cardiac function and hemodynamic performance requires a measurement of pressure from within the heart and peripheral arteries. iWorx offers several sol
utions for measuring pressure including fluid‐filled pressure transducers, catheter-tipped micro pressure sensors and non‐invasive tail cuff pressure systems.LabScribe software with the Blood Pressure Module provides built‐in software routines to perform a number of arterial and ventricular pressure calculationsFluid-Filled Catheter System
The BP-100/102 blood pressure transducer is an economical and accurate device used to measure direct arterial or venous pressure in animals using the fluid-filled catheter technique. A precision laser-trimmed chip provides accurate and linear measurements over a broad range of pressures. Pressure changes in the vessel are transmitted within the fluid-filled tube to the pressure transducer and acquired for monitoring and further analysis. Tubing is available as small as 1 mm in outside diameter making this technique well-suited for measuring pressures in very small vessels. Blood pressure systems include the transducer, cable, data recorder and software.Bladder Pressure
The BP-100/102 blood pressure transducer can also be used to measure bladder pressure.| Complete System | |
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  | RS-IBP4 : 4 Channel Invasive BP system includes
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| System Components | |
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| Transducers | |
 | BP-100 Intravascular Blood Pressure ProbeMeasures direct arterial or venous pressure in animals.BP-100RE Replacement Element for BP-100 Probe |
| BP-102 Blood Pressure TransducerWith integral 3cc flush device and stopcock, can be used to measuredirect arterial or venous pressure in animals. | |
| Recorders | |
 | IX-RA-834 RecorderThe iWorx RA Recorder is the foundation for iWorx advanced research systems. It include 4 transducer inputs, for recording 4 channels of Blood Pressure. Additional 4 channels of Blood Pressure can be recorded using the IA-400D amplifier and the 4 BNC inputs of the IX-RA-834. IX-RA-834 provides the ease of use and flexibility to speed your research. |
 | IX-404 RecorderThe iWorx 404 Recorder is an economical, high performance four channeldata recorders for use with a broad range of analog amplifiers. Therecorder offers 16-bit resolution at a maximum data collection speed of10 kHz, making it appropriate for most research applications. |
| Amplifier | |
 | IA-400DDedicated bridge amplifier for iWorx-brand transducers that providesfour channels of excitation power, gain, and noise filtration. |
| Cables | C-BNC: BNC CableC-DIN-EXT: Male/Female DIN 8 ExtensionC-DIN-ELTruwave Adapter Cable for Edwards Life sciences TRU-WAVE BP transducerC-DIN-GRASS-F Adapter Cable – Grass F to DIN 8 M (5 ft.)C-DIN-GRASS-M Adapter Cable – Grass M to DIN 8 M (5 ft.) |
- LabScribe Blood Pressure Module
- Heart Rate (HR)
- Maximum Pressure (Pmax)
- Minimum Pressure (Pmin)
- Mean Arterial Pressure (MAP)
- Systolic and diastolic pressure
- Maximum dP/dt (dP/dtmax)
- Minimum dP/dt (dP/dtmin)
- Pulse Height
- Notch Pressure
- Systolic Duration
- Diastolic Duration
- Cycle Duration
- Time To Peak
- Election Time
- Percent Recovery
- Heart Rate (HR)
- Maximum Pressure (Pmax)
- Minimum Pressure (Pmin)
- Mean Pressure (Pmean)
- End-systolic Pressure (Pes)
- End-diastolic Pressure (Ped)
- Maximum dP/dt (dP/dtmax)
- Minimum dP/dt (dP/dtmin)
- Developed Pressure - dP/dt@
- Contractility Index
- Relaxation Index
- Systolic Duration
- Diastolic Duration
- Cycle Duration
- Tension Time Index
- Relaxation Time
- Isovolumetric Time
- Tau (Weiss, Logistic, Glantz, Mirsky)
Software
LabScribe Blood Pressure Module
LS-30BP The LabScribe Blood Pressure Module acquires and analyzes data from blood pressure transducers. Data can be analyzed from ventricular and arterial signals in real-time.The software automatically calculates common indices of function from the blood pressure signal where it can easily be exported to another program for further analysis.| Arterial Pressure Calculations: | Ventricular Pressure Calculations: |
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Citations
Reigstad, Christopher S., Charles E. Salmonson, John F. Rainey, Joseph H. Szurszewski, David R. Linden, Justin L. Sonnenburg, Gianrico Farrugia, and Purna C. Kashyap. “Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells.” The FASEB Journal 29, no. 4 (2015): 1395-1403.
Dalziel, J. E., V. Mohan, J. Peters, R. C. Anderson, P. K. Gopal, and N. C. Roy. “The probiotic Escherichia coli Nissle 1917 inhibits propagating colonic contractions in the rat isolated large intestine.” Food & function 6, no. 1 (2015): 256-263.
Frias, Bárbara, João Santos, Marlene Morgado, Mónica Mendes Sousa, Susannah MY Gray, Karen D. McCloskey, Shelley Allen, Francisco Cruz, and Célia Duarte Cruz. “The Role of Brain-Derived Neurotrophic Factor (BDNF) in the Development of Neurogenic Detrusor Overactivity (NDO).” The Journal of Neuroscience 35, no. 5 (2015): 2146-2160.
Mawoza, Tariro, Dexter Tagwireyi, and Charles Nhachi. “Spasmogenic effects of Sclerocarya birrea stem bark aqueous extract on rat isolated uterine horns.” Journal of ethnopharmacology 164 (2015): 129-135.
McCarroll, Charlotte S., Charlotte L. Rossor, Linda R. Morrison, Liam J. Morrison, and Christopher M. Loughrey. “A Pre-clinical Animal Model of Trypanosoma brucei Infection Demonstrating Cardiac Dysfunction.” (2015): e0003811.
Liang, Xiaoting, and 梁小婷. “Activation of NRG1-ERBB4 signaling potentiates mesenchymal stem cell-mediated myocardial repairs.” HKU Theses Online (HKUTO) (2015).