Shopping Cart




To measure ECG  from Rodents the recommended systems are:


ECG signals can be measured with the IX-BIOx.  Measuring 2 channels of ECG, Lead I and Lead II allows LabScribe software to calculate Lead III, aVR, aVF and aVL .  EMG signals can be measured at the same time as the ECG signals.

Application note on using the IX-BIO4-SA for recording 6 lead Rat ECG.

Analysing ECG’s recorded in LabScribe with Kubios HRV



To measure  EMG from mice the recommended systems are:


Perform MVC calculations in LabScribe.

EMG analysis using LabScribe



iWorx systems, recorders and software have been used for recording ERGs in rodents and insects as noted in these Citations.


DP-301 AmplifierDifferential Amplifier (DP-301) by Warner Instruments
The DP-301 is a single channel AC/DC differential pre-amplifier highly suited for EEG, EKG and extracellular recording.

Differential Amplifier (Model 3000) by A-M Systems
The Model 3000 High-Gain AC/DC Differential Amplifier is designed for low-noise recordings from excitable tissue. Specific applications include EEG, EKG, extracelluar recordings, and more.


KIX-RA-834 8 Channel RecorderiWorx IX-RA-834 8 Channel Recorder
The iWorx RA-834C Recorder is the most advanced and feature-rich physiological data acquisition system on the market.

IX-400 Series Recorder

iWorx IX-400 Series Recorders
The iWorx 400 Series recorders are economical, high performance four, eight or sixteen channel data recorders for use with a broad range of analog amplifiers.



Samuels, Ivy S., et al. “Exclusion of Aldose Reductase as a mediator of ERG deficits in a mouse model of diabetic eye disease.Visual neuroscience 29.06 (2012): 267-274.

Wu, Jiang, et al. “Contribution of Kir4. 1 to the mouse electroretinogram.” Molecular vision 10 (2004): 650.

Wu, Jiang, et al. “Voltage-dependent calcium channel CaV1. 3 subunits regulate the light peak of the electroretinogram.” Journal of neurophysiology 97.5 (2007): 3731-3735.

Wu, Jiang, Alan D. Marmorstein, and Neal S. Peachey. “Functional abnormalities in the retinal pigment epithelium of CFTR mutant mice.” Experimental eye research 83.2 (2006): 424-428.

PEACHEY, NEAL S., J. BRETT STANTON, and ALAN D. MARMORSTEIN. “Noninvasive recording and response characteristics of the rat dc-electroretinogram.” Visual neuroscience 19.06 (2002): 693-701.

Marmorstein, Alan D., Neal S. Peachey, and Karl G. Csaky. “In vivo gene transfer as a means to study the physiology and morphogenesis of the retinal pigment epithelium in the rat.” Methods 30.3 (2003): 277-285.

Marmorstein, Alan D., et al. “A model of best vitelliform macular dystrophy in rats.Investigative ophthalmology & visual science 45.10 (2004): 3733-3739.

Wu, Jiang, Neal S. Peachey, and Alan D. Marmorstein. “Light-evoked responses of the mouse retinal pigment epithelium.” Journal of neurophysiology 91.3 (2004): 1134-1142.

Wu, Jiang, et al. “Voltage-Dependent Calcium Channel Ca.Hum. Mol. Genet (2010).

Yu, Minzhong, et al. “Age-related changes in visual function in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia.Experimental eye research 96.1 (2012): 124-131.

Won, Jungyeon, et al. “Membrane frizzled-related protein is necessary for the normal development and maintenance of photoreceptor outer segments.Visual neuroscience 25.04 (2008): 563-574.

Shen, Yi, Wan-Yu Zhang, and George CY Chiou. “Effect of naringenin on NaIO3-induced retinal pigment epithelium degeneration and laser-induced choroidal neovascularization in rats.International journal of ophthalmology 3.1 (2010): 5.

Jiang, Wei, and G. C. Chiou. “Effects of hydralazine on NaIO3-induced rat retinal pigment epithelium degeneration.” Int J Ophthalmol 8 (2008): 1504-10.

Shen, Yi, Pei Zhuang, and George CY Chiou. “Effect of Guanabenz on Rat AMD Models and Rabbit Choroidal Blood Flow.” The open ophthalmology journal 5 (2011): 27.

Zhuang, Pei, Yi Shen, and George CY Chiou. “Effects of flavone on the oxidation-induced injury of retinal pigment epithelium cells.” International journal of ophthalmology 3.2 (2010): 99.

Samuels, Ivy S., et al. “Light-evoked responses of the retinal pigment epithelium: changes accompanying photoreceptor loss in the mouse.” Journal of neurophysiology 104.1 (2010): 391-402.

Shen, Yi, et al. “Effect of Tetramethylpyrazine on RPE degeneration, choroidal blood flow and oxidative stress of RPE cells.” International journal of ophthalmology 3.3 (2010): 205.

Dalziel, J. E., K. E. Dunstan, and S. C. Finch. “Combined effects of fungal alkaloids on intestinal motility in an in vitro rat model.” Journal of animal science 91.11 (2013): 5177-5182.

Rajashekhar, Gangaraju, et al. “Regenerative therapeutic potential of adipose stromal cells in early stage diabetic retinopathy.PloS one 9.1 (2014): e84671.

Chabot, Christopher C., and Laura K. Webb. “Circadian rhythms of heart rate in freely moving and restrained American lobsters, Homarus americanus.” Marine and Freshwater Behaviour and Physiology 41.1 (2008): 29-41.


Inthachai, Tharnwimol, Suree Lekawanvijit, Sirinart Kumfu, Nattayaporn Apaijai, Wanpitak Pongkan, Siriporn C. Chattipakorn, and Nipon Chattipakorn. “Dipeptidyl peptidase‐4 inhibitor improves cardiac function by attenuating adverse cardiac remodelling in rats with chronic myocardial infarction.” Experimental physiology (2015).

Cho, Young‑Sam, Il-Gyu Ko, Chang-Ju Kim, and Khae‑Hawn Kim. “A novel intracerebral hemorrhage-induced rat model of neurogenic voiding dysfunction: Analysis of lower urinary tract function.Molecular medicine reports 12, no. 2 (2015): 2563-2569.

Mawoza, Tariro, Dexter Tagwireyi, and Charles Nhachi. “Spasmogenic effects of Sclerocarya birrea stem bark aqueous extract on rat isolated uterine horns.” Journal of ethnopharmacology 164 (2015): 129-135.

Frias, Bárbara, João Santos, Marlene Morgado, Mónica Mendes Sousa, Susannah MY Gray, Karen D. McCloskey, Shelley Allen, Francisco Cruz, and Célia Duarte Cruz. “The Role of Brain-Derived Neurotrophic Factor (BDNF) in the Development of Neurogenic Detrusor Overactivity (NDO).The Journal of Neuroscience 35, no. 5 (2015): 2146-2160.

Hake, Benjamin Matthew, Cole Waggener, Benjamin Eovaldi, Claude Zanetti, and Francis Sylvester. “Hyperbaric Oxygen Therapy Alters Vascular Reactivity Independent of Elevations in ATP.” Journal of Student Research 4, no. 1 (2015): 152-159.

Oh, Seunghoon. “Bisphenol A and 4-tert-Octylphenol Inhibit Cx46 Hemichannel Currents.The Korean Journal of Physiology & Pharmacology 19, no. 1 (2015): 73-79.

Spranger, Marty D., Jasdeep Kaur, Javier A. Sala-Mercado, Tiago M. Machado, Abhinav C. Krishnan, Alberto Alvarez, and Donal S. O’Leary. “Attenuated muscle metaboreflex-induced pressor response during postexercise muscle ischemia in renovascular hypertension.” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 308, no. 7 (2015): R650-R658.

Bradley, Sophie A., and Joern R. Steinert. “Characterisation and comparison of temporal release profiles of nitric oxide generating donors.” Journal of neuroscience methods 245 (2015): 116-124.

Steinert, Sophie A. Bradley Joern R. “Characterisation and comparison of temporal release.” Neuroscience 30 (2015): 1699-1711.

Arrowsmith, Sarah, James Neilson, Leanne Bricker, and Susan Wray. “Differing In Vitro Potencies of Tocolytics and Progesterone in Myometrium From Singleton and Twin Pregnancies.” Reproductive Sciences (2015): 1933719115597788.

View all Rats research citations on Google Scholar