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Research

Sheep

ECG/EMGmore-info-button

To measure ECG  and EMG the recommended systems are:
IX-BIO4MultiLeadThis system includes the IX-BIO4 or the IX-BIO8  or the IX-ECG12 biopotential recorder. This configuration is a cost effective solution for those only interested in measuring ECG/EMG. The gain, high-pass filter setting and low-pass filter setting can be configured via software.
Large Animal System Multi Lead ExpandableSeveral options are available depending on the research protocol and the need to acquire other signals (pressure, volume, flow, etc.) in addition to ECG.  Our multi-channel systems have software configurable gains, high-pass and low-pass filter settings. These systems allow for simultaneous recording of up to 12 ECG leads (lead I, lead II, lead III, aVR, aVL and aVF and the 6 chest leads).
Technotes:Analysing ECG’s recorded in LabScribe with Kubios HRVPerform MVC calculations in LabScribe.EMG analysis using LabScribeSoftware:ECG : LS-30ECG : LabScribe ECG Software Module is a powerful and user-friendly tool intended to automate the analysis of ECG data from a variety of species.

Blood Pressuremore-info-button

Proper assessment of cardiac function and hemodynamic performance requires a measurement of pressure from within the heart and peripheral arteries. iWorx offers several solLabScribe Blood Pressure Moduleutions for measuring pressure including fluid‐filled pressure transducers, catheter-tipped micro pressure sensors and non‐invasive tail cuff pressure systems.LabScribe software with the Blood Pressure Module provides built‐in software routines to perform a number of arterial and ventricular pressure calculations

Fluid-Filled Catheter System

The BP-100/102 blood pressure transducer is an economical and accurate device used to measure direct arterial or venous pressure in animals using the fluid-filled catheter technique. A precision laser-trimmed chip provides accurate and linear measurements over a broad range of pressures. Pressure changes in the vessel are transmitted within the fluid-filled tube to the pressure transducer and acquired for monitoring and further analysis. Tubing is available as small as 1 mm in outside diameter making this technique well-suited for measuring pressures in very small vessels. Blood pressure systems include the transducer, cable, data recorder and software.

Bladder Pressure

The BP-100/102 blood pressure transducer can also be used to measure bladder pressure.
Complete System
RS-IBP4.jpgrequest-quoteRS-IBP4 : 4 Channel Invasive BP system includes
System Components
Transducers
BP-100 ProbeBP-100  Intravascular Blood Pressure ProbeMeasures direct arterial or venous pressure in animals.BP-100RE Replacement Element for BP-100 Probe
BP-102 Transducer
 
BP-102  Blood Pressure TransducerWith integral 3cc flush device and stopcock, can be used to measuredirect arterial or venous pressure in animals.
Recorders
IX-RA-834 RecorderIX-RA-834 RecorderThe iWorx RA Recorder is the foundation for iWorx advanced research systems. It include 4 transducer inputs, for recording 4 channels of Blood Pressure. Additional 4 channels of Blood Pressure can be recorded using the IA-400D amplifier and the 4 BNC inputs of the IX-RA-834.  IX-RA-834 provides the ease of use and flexibility to speed your research.
IX-400 Series RecorderIX-404 RecorderThe iWorx 404 Recorder is an economical, high performance four channeldata recorders for use with a broad range of analog amplifiers. Therecorder offers 16-bit resolution at a maximum data collection speed of10 kHz, making it appropriate for most research applications.
Amplifier
IA-400DIA-400DDedicated bridge amplifier for iWorx-brand transducers that providesfour channels of excitation power, gain, and noise filtration.
CablesC-BNC:  BNC CableC-DIN-EXT: Male/Female DIN 8 ExtensionC-DIN-ELTruwave Adapter Cable for Edwards Life sciences TRU-WAVE BP transducerC-DIN-GRASS-F Adapter Cable – Grass F to DIN 8 M (5 ft.)C-DIN-GRASS-M Adapter Cable – Grass M to DIN 8 M (5 ft.)
Software
LabScribe Blood Pressure Module
LabScribe Blood Pressure Module
LS-BP The LabScribe Blood Pressure Module acquires and analyzes data from blood pressure transducers. Data can be analyzed from ventricular and arterial signals in real-time. The software automatically calculates common indices of function from the blood pressure signal where it can easily be exported to another program for further analysis.Arterial Pressure Calculations:
  • Heart Rate (HR)
  • Maximum Pressure (Pmax)
  • Minimum Pressure  (Pmin)
  • Mean Arterial Pressure (MAP)
  • Systolic and diastolic pressure
  • Maximum dP/dt (dP/dtmax)
  • Minimum dP/dt (dP/dtmin)
  • Pulse Height
  • Notch Pressure
  • Systolic Duration
  • Diastolic Duration
  • Cycle Duration
  • Time To Peak
  • Election Time
  • Percent Recovery
Ventricular Pressure Calculations:
  • Heart Rate (HR)
  • Maximum Pressure (Pmax)
  • Minimum Pressure (Pmin)
  • Mean Pressure (Pmean)
  • End-systolic Pressure (Pes)
  • End-diastolic Pressure (Ped)
  • Maximum dP/dt (dP/dtmax)
  • Minimum dP/dt (dP/dtmin)
  • Developed Pressure - dP/dt@
  • Contractility Index
  • Relaxation Index
  • Systolic Duration
  • Diastolic Duration
  • Cycle Duration
  • Tension Time Index
  • Relaxation Time
  • Isovolumetric Time
  • Tau (Weiss, Logistic, Glantz, Mirsky)
Detailed information about using the modules is in the LabScribe Manual

Software

LabScribe Blood Pressure Module

Zoom Image

LabScribe Blood Pressure Module
LS-BP The LabScribe Blood Pressure Module acquires and analyzes data from blood pressure transducers. Data can be analyzed from ventricular and arterial signals in real-time.The software automatically calculates common indices of function from the blood pressure signal where it can easily be exported to another program for further analysis.
Arterial Pressure Calculations:Ventricular Pressure Calculations:
  • Heart Rate (HR)
  • Maximum Pressure (Pmax)
  • Minimum Pressure (Pmin)
  • Mean Arterial Pressure (MAP)
  • Systolic and diastolic pressure
  • Maximum dP/dt (dP/dtmax)
  • Minimum dP/dt (dP/dtmin)
  • Pulse Height
  • Notch Pressure
  • Systolic Duration
  • Diastolic Duration
  • Cycle Duration
  • Time To Peak
  • Election Time
  • Percent Recovery
  • Heart Rate (HR)
  • Maximum Pressure (Pmax)
  • Minimum Pressure (Pmin)
  • Mean Pressure (Pmean)
  • End-systolic Pressure (Pes)
  • End-diastolic Pressure (Ped)
  • Maximum dP/dt (dP/dtmax)
  • Minimum dP/dt (dP/dtmin)
  • Developed Pressure
  • dP/dt@
  • Contractility Index
  • Relaxation Index
  • Systolic Duration
  • Diastolic Duration
  • Cycle Duration
  • Tension Time Index
  • Relaxation Time
  • Isovolumetric Time
  • Tau (Weiss, Logistic, Glantz, Mirsky)

Detailed information about using the modules is in the LabScribe Manual
Citations

Spranger, Marty D., Jasdeep Kaur, Javier A. Sala-Mercado, Tiago M. Machado, Abhinav C. Krishnan, Alberto Alvarez, and Donal S. O’Leary. “Attenuated muscle metaboreflex-induced pressor response during postexercise muscle ischemia in renovascular hypertension.” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 308, no. 7 (2015): R650-R658.

Jahren, Silje Ekroll, Raffael Amacher, Alberto Weber, Henriette Most, Shannon Axiak Flammer, Tobias Traupe, Michael Stoller, Stefano de Marchi, and Stijn Vandenberghe. “Effects of Thoratec pulsatile ventricular assist device timing on the abdominal aortic wave intensity pattern.” American Journal of Physiology-Heart and Circulatory Physiology 307, no. 8 (2014): H1243-H1251.

Spranger, Marty D., Jasdeep Kaur, Javier A. Sala-Mercado, Tiago M. Machado, Abhinav C. Krishnan, Alberto Alvarez, and Donal S. O’Leary. “Attenuated muscle metaboreflex-induced pressor response during postexercise muscle ischemia in renovascular hypertension.” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 308, no. 7 (2015): R650-R658.

Krupnick, Alexander Sasha, Daniel Kreisel, and Andrew Gelman. “Induction of tolerance in lung allograft transplantation.” U.S. Patent Application 14/334,660, filed July 17, 2014.

Halliez, Marie. “Novel Insights Into The Mechanisms Of Post-Infectious Irritable Bowel Syndrome Using Experimental Giardiasis.” (2014).

Pirbodaghi, Tohid, Shannon Axiak, Alberto Weber, Thomas Gempp, and Stijn Vandenberghe. “Pulsatile control of rotary blood pumps: Does the modulation waveform matter?.The Journal of thoracic and cardiovascular surgery 144, no. 4 (2012): 970-977.

Dalziel, J. E., K. E. Dunstan, and S. C. Finch. “Combined effects of fungal alkaloids on intestinal motility in an rat model.” Journal of animal science 91, no. 11 (2013): 5177-5182.

Pirbodaghi, Tohid, Alberto Weber, Shannon Axiak, Thierry Carrel, and Stijn Vandenberghe. “Asymmetric speed modulation of a rotary blood pump affects ventricular unloading.European Journal of Cardio-Thoracic Surgery 43, no. 2 (2013): 383-388.

Atchison, Douglas K., M. Cecilia Ortiz-Capisano, and William H. Beierwaltes. “Acute activation of the calcium-sensing receptor inhibits plasma renin activity in vivo.” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 299, no. 4 (2010): R1020-R1026.

View all of the Sheep research citations on Google Scholar

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